Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques

S Jegaskanda; TH Amarasena; KL Laurie; HX Tan; J Butler; MS Parsons; S Alcantara; J Petravic; MP Davenport; AC Hurt; PC Reading; SJ Kent

Journal article

Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques

S Jegaskanda, TH Amarasena, KL Laurie, HX Tan, J Butler, MS Parsons, S Alcantara, J Petravic, MP Davenport, AC Hurt, PC Reading, SJ Kent

Journal of Virology | Published : 2013

DOI: 10.1128/JVI.01666-13

Abstract

Yearly vaccination with the trivalent inactivated influenza vaccine (TIV) is recommended, since current vaccines induce little cross neutralization to divergent influenza strains. Whether the TIV can induce antibody-dependent cellular cytotoxicity (ADCC) responses that can cross-recognize divergent influenza virus strains is unknown. We immunized 6 influenza-naive pigtail macaques twice with the 2011-2012 season TIV and then challenged the macaques, along with 12 control macaques, serially with H1N1 and H3N2 viruses. We measured ADCC responses in plasma to a panel of H1 and H3 hemagglutinin (HA) proteins and influenza virus-specific CD8 T cell (CTL) responses using a sensitive major histocom..

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University of Melbourne Researchers

Patrick Reading Author

Stephen Kent Author

Hyon Xhi Tan Author

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The work was supported by Australian National Health and Medical Research Council (NHMRC) awards 628331 and 510488. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.